column efficiency, number of theoretical plates, particle size, particle diameter

Three major ways to influence column efficiency in your favor

Bart explains how particle size, column packing and pore size affect column efficiency and resolution in chromatography →

freeze drying, lyophilization, primary drying, endpoint determination, temperature

How to use temperature to assess if primary freeze drying is finished

Bart describes how temperature could be used for endpoint determination of the primary drying step in lyophilization →

column efficiency, theoretical plates, resolution, chromatography

Why you should care about column efficiency

Bart explains how column efficiency, or the number of theoretical plates, affect resolution in chromatography →

lyophilization, freeze drying, pressure gradient, temperature gradient

Why pressure gradients are the main drivers in improving sublimation rates

Bart discusses why a good pressure gradient is the most efficient way to improve freeze-drying rates →

chromatography safety, sample protection, user protection

Putting safety first during the chromatography process

Bart discusses how to maximize the safety of user, sample and the surroundings during the chromatography process →

heated shelves, heatable shelves, lyophilization, freeze-drying

A pretty hot way to speed up the freeze-drying process

Bart offers theory and experimental data on how heated shelves can speed up the freeze drying process →

HPLC columns, column care, column maintenance, cartridges, guard columns, pre-columns, preperative HPLC, prep HPLC

Two essential aids for proper column maintenance

Bart discusses the role of pre-guards, column guards and RFID technology in proper cartridge and column maintenance →

freeze drying, shell freezing, manifold freeze drying

Shall we use shell freezing to speed up manifold freeze drying?

Bart discusses the benefits of shell freezing over bulk freezing in speeding up the manifold freeze drying process →

chromatography hazards, green chromatography

Beware: Protecting yourself and the environment against chromatography hazards

Safe, green chromatography? Yes, you can! →

organic solvents, laboratory freeze drying, lyophilization

How to effectively use organic solvents in lyophilization

Bart offers advice on how to incorporate challenging organic solvents into your laboratory freeze drying process →

chromatography blog, lyophilization, laboratory freeze drying

The blog gets older, falls in love and branches out

Bart's blog celebrates its first birthday by welcoming a new guest to the party. Lyophilization will now get regular coverage on the blog! →